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Journal of Biomedical Optics

Fat tissue histological study at indocyanine green-mediated photothermal/photodynamic treatment of the skin in vivo
Author(s): Irina Yu. Yanina; Valery V. Tuchin; Nikita A. Navolokin; Olga V. Matveeva; Alla B. Bucharskaya; Galina N. Maslyakova; Gregory B. Altshuler
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Paper Abstract

Histological slices of skin samples with the subcutaneous adipose tissue after photothermal/photodynamic treatment are analyzed. In the case of subcutaneous indocyanine green injection and 808-nm diode laser exposure of the rat skin site in vivo, the greatest changes in tissue condition were observed. Processes were characterized by dystrophy, necrosis, and desquamation of the epithelial cells, swelling and necrosis of the connective tissue, and widespread necrosis of the subcutaneous adipose tissue. The obtained data are useful for safe layer-by-layer dosimetry of laser illumination of ICG-stained adipose tissue for treatment of obesity and cellulite.

Paper Details

Date Published: 7 May 2012
PDF: 10 pages
J. Biomed. Opt. 17(5) 058002 doi: 10.1117/1.JBO.17.5.058002
Published in: Journal of Biomedical Optics Volume 17, Issue 5
Show Author Affiliations
Irina Yu. Yanina, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Nikita A. Navolokin, Saratov State Medical Univ. (Russian Federation)
Olga V. Matveeva, Saratov State Medical Univ. (Russian Federation)
Alla B. Bucharskaya, Saratov State Medical Univ. (Russian Federation)
Galina N. Maslyakova, Saratov State Medical Univ. (Russian Federation)
Gregory B. Altshuler, Palomar Medical Technologies, Inc. (United States)

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