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Journal of Biomedical Optics

Lifetime-based photoacoustic oxygen sensing in vivo
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Paper Abstract

The determination of oxygen levels in blood and other tissues in vivo is critical for ensuring proper body functioning, for monitoring the status of many diseases, such as cancer, and for predicting the efficacy of therapy. Here we demonstrate, for the first time, a lifetime-based photoacoustic technique for the measurement of oxygen in vivo, using an oxygen sensitive dye, enabling real time quantification of blood oxygenation. The results from the main artery in the rat tail indicated that the lifetime of the dye, quantified by the photoacoustic technique, showed a linear relationship with the blood oxygenation levels in the targeted artery.

Paper Details

Date Published: 4 May 2012
PDF: 5 pages
J. Biomed. Opt. 17(5) 057004 doi: 10.1117/1.JBO.17.5.057004
Published in: Journal of Biomedical Optics Volume 17, Issue 5
Show Author Affiliations
Aniruddha Ray, Univ. of Michigan (United States)
Raoul Kopelman, Univ. of Michigan (United States)
Justin R. Rajian, Univ. of Michigan Medical School (United States)
Xueding Wang, Univ. of Michigan Medical School (United States)
Yong-Eun K. Lee, Univ. of Michigan (United States)

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