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Journal of Biomedical Optics • Open Access

Performance of a lookup table-based approach for measuring tissue optical properties with diffuse optical spectroscopy

Paper Abstract

Diffuse optical spectroscopy (DOS) provides a powerful tool for fast and noninvasive disease diagnosis. The ability to leverage DOS to accurately quantify tissue optical parameters hinges on the model used to estimate light-tissue interaction. We describe the accuracy of a lookup table (LUT)-based inverse model for measuring optical properties under different conditions relevant to biological tissue. The LUT is a matrix of reflectance values acquired experimentally from calibration standards of varying scattering and absorption properties. Because it is based on experimental values, the LUT inherently accounts for system response and probe geometry. We tested our approach in tissue phantoms containing multiple absorbers, different sizes of scatterers, and varying oxygen saturation of hemoglobin. The LUT-based model was able to extract scattering and absorption properties under most conditions with errors of less than 5 percent. We demonstrate the validity of the lookup table over a range of source-detector separations from 0.25 to 1.48 mm. Finally, we describe the rapid fabrication of a lookup table using only six calibration standards. This optimized LUT was able to extract scattering and absorption properties with average RMS errors of 2.5 and 4 percent, respectively.

Paper Details

Date Published: 20 April 2012
PDF: 9 pages
J. Biomed. Opt. 17(5) 057001 doi: 10.1117/1.JBO.17.5.057001
Published in: Journal of Biomedical Optics Volume 17, Issue 5
Show Author Affiliations
Brandon S. Nichols, The Univ. of Texas at Austin (United States)
Narasimhan Rajaram, The Univ. of Texas at Austin (United States)
James W. Tunnell, The Univ. of Texas at Austin (United States)

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