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Journal of Biomedical Optics

Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system
Author(s): Haixin Ke; Changjun Liu; Lihong V. Wang; Todd N. Erpelding; Ladislav Jankovic
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Paper Abstract

We developed a novel trimodality system for human breast imaging by integrating photoacoustic (PA) and thermoacoustic (TA) imaging techniques into a modified commercial ultrasound scanner. Because light was delivered with an optical assembly placed within the microwave antenna, no mechanical switching between the microwave and laser sources was needed. Laser and microwave excitation pulses were interleaved to enable PA and TA data acquisition in parallel at a rate of 10 frames per second. A tube (7 mm inner diameter) filled with oxygenated bovine blood or 30 mM methylene blue dye was successfully detected in PA images in chicken breast tissue at depths of 6.6 and 8.4 cm, respectively, for the first time. The SNRs at these depths reached ∼ 24 and ∼ 15  dB, respectively, by averaging 200 signal acquisitions. Similarly, a tube (13 mm inner diameter) filled with saline solution (0.9%) at a depth of 4.4 cm in porcine fat tissue was successfully detected in TA images. The PA axial, lateral, and elevational resolutions were 640 μm, 720 μm, and 3.5 mm, respectively, suitable for breast cancer imaging. A PA noise-equivalent sensitivity to methylene blue solution of 260 nM was achieved in chicken tissue at a depth of 3.4 cm.

Paper Details

Date Published: 4 May 2012
PDF: 7 pages
J. Biomed. Opt. 17(5) 056010 doi: 10.1117/1.JBO.17.5.056010
Published in: Journal of Biomedical Optics Volume 17, Issue 5
Show Author Affiliations
Haixin Ke, Washington Univ. in St. Louis (United States)
Changjun Liu, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)
Todd N. Erpelding, Philips Research North America (United States)
Ladislav Jankovic, Philips Research North America (United States)

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