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Journal of Biomedical Optics • Open Access

Temperature-modulated fluorescence tomography based on both concentration and lifetime contrast
Author(s): Yuting Lin; Tiffany C. Kwong; Gultekin Gulsen; Linden Bolisay

Paper Abstract

It is challenging to image fluorescence objects with high spatial resolution in a highly scattering medium. Recently reported temperature-sensitive indocyanine green-loaded pluronic nanocapsules can potentially alleviate this problem. Here we demonstrate a frequency-domain temperature-modulated fluorescence tomography system that could acquire images at high intensity-focused ultrasound resolution with use of these nanocapsules. The system is experimentally verified with a phantom study, where a 3-mm fluorescence object embedded 2 cm deep in a turbid medium is successfully recovered based on both intensity and lifetime contrast.

Paper Details

Date Published: 4 May 2012
PDF: 5 pages
J. Biomed. Opt. 17(5) 056007 doi: 10.1117/1.JBO.17.5.056007
Published in: Journal of Biomedical Optics Volume 17, Issue 5
Show Author Affiliations
Yuting Lin, Univ. of California, Irvine (United States)
Tiffany C. Kwong, Univ. of California, Irvine (United States)
Gultekin Gulsen, Univ. of California, Irvine (United States)
Linden Bolisay, InnoSense LLC (United States)


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