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Journal of Biomedical Optics • Open Access

Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo

Paper Abstract

We report a novel small-animal whole-body imaging system called ring-shaped confocal photoacoustic computed tomography (RC-PACT). RC-PACT is based on a confocal design of free-space ring-shaped light illumination and 512-element full-ring ultrasonic array signal detection. The free-space light illumination maximizes the light delivery efficiency, and the full-ring signal detection ensures a full two-dimensional view aperture for accurate image reconstruction. Using cylindrically focused array elements, RC-PACT can image a thin cross section with 0.10 to 0.25 mm in-plane resolutions and 1.6 s/frame acquisition time. By translating the mouse along the elevational direction, RC-PACT provides a series of cross-sectional images of the brain, liver, kidneys, and bladder.

Paper Details

Date Published: 4 May 2012
PDF: 4 pages
J. Biomed. Opt. 17(5) 050506 doi: 10.1117/1.JBO.17.5.050506
Published in: Journal of Biomedical Optics Volume 17, Issue 5
Show Author Affiliations
Jun Xia, Washington Univ. in St. Louis (United States)
Muhammad R. Chatni, Washington Univ. in St. Louis (United States)
Konstantin I. Maslov, Washington Univ. in St. Louis (United States)
Zijian Guo, Washington Univ. in St. Louis (United States)
Kun Wang, Washington Univ. in St. Louis (United States)
Mark A. Anastasio, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


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