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Journal of Biomedical Optics • Open Access

Label free in vivo laser speckle imaging of blood and lymph vessels
Author(s): Vyacheslav Kalchenko; Yuri Kuznetsov; Alon Harmelin; Igor V. Meglinski

Paper Abstract

The peripheral lymphatic vascular system is a part of the immune body system comprising a complex network of lymph vessels and nodes that are flowing lymph toward the heart. Traditionally the imaging of lymphatic vessels is based on the conventional imaging modalities utilizing contrast fluorescence materials. Given the important role of the lymphatic system there is a critical need for the development of noninvasive imaging technologies for functional quantitative diagnosis of the lymph vessels and lymph flow without using foreign chemicals. We report a label free methodology for noninvasive in vivo imaging of blood and lymph vessels, using long-exposure laser speckle imaging approach. This approach entails great promise in the noninvasive studies of tissues blood and lymph vessels distribution in vivo.

Paper Details

Date Published: 4 May 2012
PDF: 4 pages
J. Biomed. Opt. 17(5) 050502 doi: 10.1117/1.JBO.17.5.050502
Published in: Journal of Biomedical Optics Volume 17, Issue 5
Show Author Affiliations
Vyacheslav Kalchenko, Weizmann Institute of Science (Israel)
Yuri Kuznetsov, Weizmann Institute of Science (Israel)
Alon Harmelin, Weizmann Institute of Science (Israel)
Igor V. Meglinski, Univ. of Otago (New Zealand)

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