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Journal of Biomedical Optics • Open Access

In vivo measurement of the shape of the tissue-refractive-index correlation function and its applicationto detection of colorectal field carcinogenesis
Author(s): Andrew J. Gomes; Sarah K. Ruderman; Vadim Backman; Mart Dela Cruz; Ramesh K. Wali; Hemant K. Roy

Paper Abstract

Polarization-gated spectroscopy is an established method to depth-selectively interrogate the structural properties of biological tissue. We employ this method in vivo in the azoxymethane (AOM)-treated rat model to monitor the morphological changes that occur in the field of a tumor during early carcinogenesis. The results demonstrate a statistically significant change in the shape of the refractive-index correlation function for AOM-treated rats versus saline-treated controls. Since refractive index is linearly proportional to mass density, these refractive-index changes can be directly linked to alterations in the spatial distribution patterns of macromolecular density. Furthermore, we found that alterations in the shape of the refractive-index correlation function shape were an indicator of both present and future risk of tumor development. These results suggest that noninvasive measurement of the shape of the refractive-index correlation function could be a promising marker of early cancer development.

Paper Details

Date Published: 18 April 2012
PDF: 9 pages
J. Biomed. Opt. 17(4) 047005 doi: 10.1117/1.JBO.17.4.047005
Published in: Journal of Biomedical Optics Volume 17, Issue 4
Show Author Affiliations
Andrew J. Gomes, Northwestern Univ. (United States)
Sarah K. Ruderman, Northwestern Univ. (United States)
Vadim Backman, Northwestern Univ. (United States)
Mart Dela Cruz, NorthShore Univ. HealthSystem (United States)
Ramesh K. Wali, NorthShore Univ. HealthSystem (United States)
Hemant K. Roy, NorthShore Univ. HealthSystem (United States)

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