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Journal of Biomedical Optics • Open Access

Photoacoustic/ultrasound dual-modality contrast agent and its application to thermotherapy
Author(s): Yu-Hsin Wang; Pai-Chi Li; Ai-Ho Liao; Jui-Hao Chen; Churng-Ren Wang

Paper Abstract

This study investigates a photoacoustic/ultrasound dual-modality contrast agent, including extending its applications from image-contrast enhancement to combined diagnosis and therapy with site-specific targeting. The contrast agent comprises albumin-shelled microbubbles with encapsulated gold nanorods (AuMBs). The gas-filled microbubbles, whose diameters range from submicrometer to several micrometers, are not only echogenic but also can serve as drug-delivery vehicles. The gold nanorods are used to enhance the generation of both photoacoustic and photothermal signals. The optical absorption peak of the gold nanorods is tuned to 760 nm and is invariant after microbubble encapsulation. Dual-modality contrast enhancement is first described here, and the applications to cellular targeting and laser-induced thermotherapy in a phantom are demonstrated. Photoacoustic imaging can be used to monitor temperature increases during the treatment. The targeting capability of AuMBs was verified, and the temperature increased by 26°C for a laser power of 980 mW, demonstrating the potential of combined diagnosis and therapy with the dual-modality agent. Targeted photo- or acoustic-mediated delivery is also possible.

Paper Details

Date Published: 3 April 2012
PDF: 9 pages
J. Biomed. Opt. 17(4) 045001 doi: 10.1117/1.JBO.17.4.045001
Published in: Journal of Biomedical Optics Volume 17, Issue 4
Show Author Affiliations
Yu-Hsin Wang, National Taiwan Univ. (Taiwan)
Pai-Chi Li, National Taiwan Univ. (Taiwan)
Ai-Ho Liao, National Taiwan Univ. of Science and Technology (Taiwan)
Jui-Hao Chen, National Chung Cheng Univ. (Taiwan)
Churng-Ren Wang, National Chung Cheng Univ. (Taiwan)


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