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Journal of Biomedical Optics • Open Access

Monitoring of tumor response to cisplatin by subsurface fluorescence molecular tomography
Author(s): Fei Liu; Xu Cao; Wei He; Jinping Song; Zhongquan Dai; Bin Zhang; Jianwen Luo; Jing Bai; Yinghui Li

Paper Abstract

Subsurface fluorescence molecular tomography (FMT) has promising potential for noninvasive characterization of molecular and cellular activities in small animals by tomographic means in reflectance geometry. In this work, subsurface FMT is employed to monitor the therapeutic response of cisplatin in tumor-bearing mice in vivo. The localization and quantification accuracy of subsurface FMT are demonstrated in phantom. In the in vivo study, the red fluorescent protein activities not only on the surface but in the interior tumor are tracked three-dimensionally during the antitumor treatment.

Paper Details

Date Published: 6 April 2012
PDF: 4 pages
J. Biomed. Opt. 17(4) 040504 doi: 10.1117/1.JBO.17.4.040504
Published in: Journal of Biomedical Optics Volume 17, Issue 4
Show Author Affiliations
Fei Liu, Tsinghua Univ. (China)
Xu Cao, Tsinghua Univ. (China)
Wei He, Tsinghua Univ. (China)
Jinping Song, Tsinghua Univ. (China)
Zhongquan Dai, Tsinghua Univ. (China)
Bin Zhang, Tsinghua Univ. (China)
Jianwen Luo, Tsinghua Univ. (China)
Jing Bai, Tsinghua Univ. (China)
Yinghui Li, China Astronaut Research and Training Ctr. (China)

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