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Journal of Biomedical Optics • Open Access

Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging
Author(s): Erin M. Buckley; Dalton Hance; Jennifer M. Lynch; Rickson C. Mesquita; Arjun G. Yodh; Daniel J. Licht; Thomas Pawlowski; Felice B. Wilson; Mark A. Fogel; Turgut Durduran; Laura K. Diaz; Mary E. Putt

Paper Abstract

Diffuse correlation spectroscopy (DCS) is a novel optical technique that appears to be an excellent tool for assessing cerebral blood flow in a continuous and non-invasive manner at the bedside. We present new clinical validation of the DCS methodology by demonstrating strong agreement between DCS indices of relative cerebral blood flow and indices based on phase-encoded velocity mapping magnetic resonance imaging (VENC MRI) of relative blood flow in the jugular veins and superior vena cava. Data were acquired from 46 children with single ventricle cardiac lesions during a hypercapnia intervention. Significant increases in cerebral blood flow, measured both by DCS and by VENC MRI, as well as significant increases in oxyhemoglobin concentration, and total hemoglobin concentration, were observed during hypercapnia. Comparison of blood flow changes measured by VENC MRI in the jugular veins and by DCS revealed a strong linear relationship, R = 0.88, p<0.001, slope = 0.91±0.07. Similar correlations were observed between DCS and VENC MRI in the superior vena cava, R = 0.77, slope = 0.99±0.12, p<0.001. The relationship between VENC MRI in the aorta and DCS, a negative control, was weakly correlated, R = 0.46, slope = 1.77±0.45, p<0.001.

Paper Details

Date Published: 27 March 2012
PDF: 9 pages
J. Biomed. Opt. 17(3) 037007 doi: 10.1117/1.JBO.17.3.037007
Published in: Journal of Biomedical Optics Volume 17, Issue 3
Show Author Affiliations
Erin M. Buckley, Univ. of Pennsylvania (United States)
Dalton Hance, Univ. of Pennsylvania (United States)
Jennifer M. Lynch, Univ. of Pennsylvania (United States)
Rickson C. Mesquita, Univ. of Pennsylvania (United States)
Arjun G. Yodh, Univ. of Pennsylvania (United States)
Daniel J. Licht, The Children's Hospital of Philadelphia (United States)
Thomas Pawlowski, The Children's Hospital of Philadelphia (United States)
Felice B. Wilson, The Children's Hospital of Philadelphia (United States)
Mark A. Fogel, The Children's Hospital of Philadelphia (United States)
Turgut Durduran, ICFO - Institut de Ciències Fotòniques (Spain)
Laura K. Diaz, The Children's Hospital of Philadelphia (United States)
Mary E. Putt, Univ. of Pennsylvania (United States)


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