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Journal of Biomedical Optics • Open Access

Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source

Paper Abstract

We developed optical coherence photoacoustic microscopy (OC-PAM) to demonstrate that the functions of optical coherence tomography (OCT) and photoacoustic microscopy (PAM) can be achieved simultaneously by using a single illuminating light source. We used a pulsed broadband laser centered at 580 nm and detected the absorbed photons through photoacoustic detection and the back-scattered photons with an interferometer. In OC-PAM, each laser pulse generates both one OCT A-line and one PAM A-line simultaneously; as a result, the two imaging modalities are intrinsically co-registered in the lateral directions. In vivo images of the mouse ear were acquired to demonstrate the capabilities of OC-PAM.

Paper Details

Date Published: 2 March 2012
PDF: 4 pages
J. Biomed. Opt. 17(3) 030502 doi: 10.1117/1.JBO.17.3.030502
Published in: Journal of Biomedical Optics Volume 17, Issue 3
Show Author Affiliations
Xiangyang Zhang, The Univ. of Southern California (United States)
Shuliang Jiao, The Univ. of Southern California (United States)
Hao Zhang, Northwestern Univ. (United States)


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