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Journal of Biomedical Optics

Angiography with a multifunctional line scanning ophthalmoscope
Author(s): Daniel X. Hammer; R. Daniel Ferguson; Ankit H. Patel; Vanessa Vazquez; Deeba Husain
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Paper Abstract

A multifunctional line scanning ophthalmoscope (mLSO) was designed, constructed, and tested on human subjects. The mLSO could sequentially acquire wide-field, confocal, near-infrared reflectance, fluorescein angiography (FA), and indocyanine green angiography (ICGA) retinal images. The system also included a retinal tracker (RT) and a photodynamic therapy laser treatment port. The mLSO was tested in a pilot clinical study on human subjects with and without retinal disease. The instrument exhibited robust retinal tracking and high-contrast line scanning imaging. The FA and ICGA angiograms showed a similar appearance of hyper- and hypo-pigmented disease features and a nearly equivalent resolution of fine capillaries compared to a commercial flood-illumination fundus imager. An mLSO-based platform will enable researchers and clinicians to image human and animal eyes with a variety of modalities and deliver therapeutic beams from a single automated interface. This approach has the potential to improve patient comfort and reduce imaging session times, allowing clinicians to better diagnose, plan, and conduct patient procedures with improved outcomes.

Paper Details

Date Published: 13 March 2012
PDF: 12 pages
J. Biomed. Opt. 17(2) 026008 doi: 10.1117/1.JBO.17.2.026008
Published in: Journal of Biomedical Optics Volume 17, Issue 2
Show Author Affiliations
Daniel X. Hammer, Physical Sciences Inc. (United States)
R. Daniel Ferguson, Physical Sciences Inc. (United States)
Ankit H. Patel, Physical Sciences Inc. (United States)
Vanessa Vazquez, Boston Medical Ctr. (United States)
Deeba Husain, Boston Medical Ctr. (United States)

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