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Journal of Biomedical Optics

Automatic three-dimensional registration of intravascular optical coherence tomography images
Author(s): Giovanni J. Ughi; Matilda Larsson; Christophe Dubois; Peter R. Sinnaeve; Walter Desmet; Jan D'Hooge; Tom Adriaenssens; Mark Coosemans
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Paper Abstract

Intravascular optical coherence tomography (IV-OCT) is a catheter-based high-resolution imaging technique able to visualize the inner wall of the coronary arteries and implanted devices in vivo with an axial resolution below 20 μm. IV-OCT is being used in several clinical trials aiming to quantify the vessel response to stent implantation over time. However, stent analysis is currently performed manually and corresponding images taken at different time points are matched through a very labor-intensive and subjective procedure. We present an automated method for the spatial registration of IV-OCT datasets. Stent struts are segmented through consecutive images and three-dimensional models of the stents are created for both datasets to be registered. The two models are initially roughly registered through an automatic initialization procedure and an iterative closest point algorithm is subsequently applied for a more precise registration. To correct for nonuniform rotational distortions (NURDs) and other potential acquisition artifacts, the registration is consecutively refined on a local level. The algorithm was first validated by using an in vitro experimental setup based on a polyvinyl-alcohol gel tubular phantom. Subsequently, an in vivo validation was obtained by exploiting stable vessel landmarks. The mean registration error in vitro was quantified to be 0.14 mm in the longitudinal axis and 7.3-deg mean rotation error. In vivo validation resulted in 0.23 mm in the longitudinal axis and 10.1-deg rotation error. These results indicate that the proposed methodology can be used for automatic registration of in vivo IV-OCT datasets. Such a tool will be indispensable for larger studies on vessel healing pathophysiology and reaction to stent implantation. As such, it will be valuable in testing the performance of new generations of intracoronary devices and new therapeutic drugs.

Paper Details

Date Published: 5 March 2012
PDF: 12 pages
J. Biomed. Opt. 17(2) 026005 doi: 10.1117/1.JBO.17.2.026005
Published in: Journal of Biomedical Optics Volume 17, Issue 2
Show Author Affiliations
Giovanni J. Ughi, Katholieke Univ. Leuven (Belgium)
Matilda Larsson, Katholieke Univ. Leuven (Sweden)
Christophe Dubois, Katholieke Univ. Leuven (Belgium)
Peter R. Sinnaeve, Katholieke Univ. Leuven (Belgium)
Walter Desmet, Katholieke Univ. Leuven (Belgium)
Jan D'Hooge, Katholieke Univ. Leuven (Belgium)
Tom Adriaenssens, Univ. Hospitals Leuven (Belgium)
Mark Coosemans, Univ. Hospitals Leuven (Belgium)

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