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Journal of Biomedical Optics • Open Access

Normal and system lupus erythematosus red blood cell interactions studied by double trap optical tweezers: direct measurements of aggregation forces
Author(s): Maria Khokhlova; Eugeny V. Lyubin; Alexander G. Zhdanov; Andrey A. Fedyanin; Sophia Yu. Rykova; Irina A. Sokolova

Paper Abstract

Direct measurements of aggregation forces in piconewton range between two red blood cells in pair rouleau are performed under physiological conditions using double trap optical tweezers. Aggregation and disaggregation properties of healthy and pathologic (system lupus erythematosis) blood samples are analyzed. Strong difference in aggregation speed and behavior is revealed using the offered method which is proposed to be a promising tool for SLE monitoring at single cell level.

Paper Details

Date Published: 22 February 2012
PDF: 6 pages
J. Biomed. Opt. 17(2) 025001 doi: 10.1117/1.JBO.17.2.025001
Published in: Journal of Biomedical Optics Volume 17, Issue 2
Show Author Affiliations
Maria Khokhlova, Lomonosov Moscow State Univ. (Russian Federation)
Eugeny V. Lyubin, Lomonosov Moscow State Univ. (Russian Federation)
Alexander G. Zhdanov, Lomonosov Moscow State Univ. (Russian Federation)
Andrey A. Fedyanin, Lomonosov Moscow State Univ. (Russian Federation)
Sophia Yu. Rykova, Lomonosov Moscow State Univ. (Russian Federation)
Irina A. Sokolova, Lomonosov Moscow State Univ. (Russian Federation)


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