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Journal of Biomedical Optics

Real-time phase-contrast imaging of photothermal treatment of head and neck squamous cell carcinoma: an in vitro study of macrophages as a vector for the delivery of gold nanoshells
Author(s): Taeseok D. Yang; Wonshik Choi; Tai Hyun Yoon; Kyoung Jin Lee; Jae-Seung Lee; Sang Hun Han; Min-Goo Lee; Hong Soon Yim; Kyung Min Choi; Min Woo Park; Kwang-Yoon Jung; Seung-Kuk Baek
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Paper Abstract

Photothermal treatment (PTT) using nanoparticles has gained attention as a promising alternative therapy for malignant tumors. One strategy for increasing the selectivity of PTT is the use of macrophages as a cellular vector for delivering nanoparticles. The aim of the present study is to examine the use of macrophages as a cellular vector for efficient PTT and determine the appropriate irradiation power and time of a near-infrared (NIR) laser using real-time phase-contrast imaging. Thermally induced injury and death of cancer cells were found to begin at 44°C to 45°C, which was achieved using the PTT effect with gold nanoshells (NS) and irradiation with a NIR laser at a power of 2 W for 5 min. The peritoneal macrophage efficiently functioned as a cellular vector for the NS, and the cancer cells surrounding the NS-loaded macrophages selectively lost their cellular viability after being irradiated with the NIR laser.

Paper Details

Date Published: 12 December 2012
PDF: 8 pages
J. Biomed. Opt. 17(12) 128003 doi: 10.1117/1.JBO.17.12.128003
Published in: Journal of Biomedical Optics Volume 17, Issue 12
Show Author Affiliations
Taeseok D. Yang, Korea Univ. (Korea, Republic of)
Wonshik Choi, Korea Univ. (Korea, Republic of)
Tai Hyun Yoon, Korea Univ. (Republic of Korea)
Kyoung Jin Lee, Korea Univ. (Korea, Republic of)
Jae-Seung Lee, Korea Univ. (Korea, Republic of)
Sang Hun Han, Korea Univ. (Korea, Republic of)
Min-Goo Lee, Korea Univ. (Korea, Republic of)
Hong Soon Yim, Korea Univ. (Korea, Republic of)
Kyung Min Choi, Korea Univ. (Korea, Republic of)
Min Woo Park, Korea Univ. (Republic of Korea)
Kwang-Yoon Jung, Korea Univ. (Korea, Republic of)
Seung-Kuk Baek, Korea Univ. (Korea, Republic of)

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