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Journal of Biomedical Optics • Open Access

Reduction of thermal damage in photodynamic therapy by laser irradiation techniques
Author(s): Hyun Soo Lim

Paper Abstract

General application of continuous-wave (CW) laser irradiation modes in photodynamic therapy can cause thermal damage to normal tissues in addition to tumors. A new photodynamic laser therapy system using a pulse irradiation mode was optimized to reduce nonspecific thermal damage. In in vitro tissue specimens, tissue energy deposition rates were measured in three irradiation modes, CW, pulse, and burst-pulse. In addition, methods were tested for reducing variations in laser output and specific wavelength shifts using a thermoelectric cooler and thermistor. The average temperature elevation per 2

Paper Details

Date Published: 7 December 2012
PDF: 9 pages
J. Biomed. Opt. 17(12) 128001 doi: 10.1117/1.JBO.17.12.128001
Published in: Journal of Biomedical Optics Volume 17, Issue 12
Show Author Affiliations
Hyun Soo Lim, Chungnam National Univ. (Korea, Republic of)

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