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Journal of Biomedical Optics

Complex conjugate artifact-free adaptive optics optical coherence tomography of <italic<in vivo</italic< human optic nerve head
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Paper Abstract

We acquired <italic<in vivo</italic< images of the human optic nerve head (ONH) using an adaptive optics—optical coherence tomography (AO-OCT) system. In order to improve imaging of the lamina cribrosa in the ONH with high lateral resolution and sensitivity, we implemented a complex conjugate artifact-free Fourier domain OCT (Fd-OCT) acquisition scheme with a reference arm-based phase shifting method. This allowed positioning of the lamina cribrosa structures near the zero path length difference where AO-OCT imaging achieves highest sensitivity. Implementation of our complex conjugate artifact removal (CCR) method required constant phase shifts between consecutive axial scans (A-scans), generated by continuous beam path-length changes from offsetting the pivot point of the scanning mirror placed in the reference arm. Fourier transform along the transverse axis and a filtering algorithm allowed reconstruction of CCR AO-OCT images. The suppression ratio of the mirror artifact was approximately 22 dB (at 18,000 A-scans per second acquisition speed) with a paperboard test target and an optimum phase-shift value. Finally, we reconstructed the three-dimensional structure of human ONH with enhanced depth range and sensitivity using CCR AO-OCT.

Paper Details

Date Published: 3 December 2012
PDF: 6 pages
J. Biomed. Opt. 17(12) 126005 doi: 10.1117/1.JBO.17.12.126005
Published in: Journal of Biomedical Optics Volume 17, Issue 12
Show Author Affiliations
Dae Yu Kim, UC Davis Medical Ctr. (United States)
John S. Werner, UC Davis Medical Ctr. (United States)
Robert J. Zawadzki, UC Davis Medical Ctr. (United States)

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