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Journal of Biomedical Optics • Open Access

Enhanced photocoagulation with catheter-based diffusing optical device

Paper Abstract

A novel balloon catheter-based diffusing optical device was designed and evaluated to assist in treating excessive menstrual bleeding. A synthetic fused-silica fiber was micro-machined precisely to create scattering segments on a 25 mm long fiber tip for uniform light distribution. A visible wavelength (<b<λ = 532 nm</b<) was used to specifically target the endometrium due to the high vascularity of the uterine wall. Optical simulation presented 30% wider distribution of photons along with approximately 40% higher irradiance induced by addition of a glass cap to the diffuser tip. Incorporation of the optical diffuser with a polyurethane balloon catheter considerably enhanced coagulation depth and area (i.e., 3.5 mm and <b<18.9 cm2</b< at 1 min irradiation) in tissue in vitro. The prototype device demonstrated the coagulation necrosis of <b<2.8±1.2 mm (n=18)</b< and no thermal damage to myometrium in in vivo caprine models. A prototype 5 cm long balloon catheter-assisted optical diffuser was also evaluated with a cadaveric human uterus to confirm the coagulative response of the uterine tissue as well as to identify the further design improvement and clinical applicability. The proposed catheter-based diffusing optical device can be a feasible therapeutic tool to photocoagulate endometrial cell layers in an efficient and safe manner.

Paper Details

Date Published: 15 November 2012
PDF: 9 pages
J. Biomed. Opt. 17(11) 118001 doi: 10.1117/1.JBO.17.11.118001
Published in: Journal of Biomedical Optics Volume 17, Issue 11
Show Author Affiliations
Hyun Wook Kang, Pukyong National Univ. (Korea, Republic of)
Jeehyun Kim, Kyungpook National Univ. (Korea, Republic of)
Junghwan Oh, Pukyong National Univ. (Korea, Republic of)

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