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Journal of Biomedical Optics

Detection of cerebral autoregulation by near-infrared spectroscopy in neonates: performance analysis of measurement methods
Author(s): Alexander Caicedo; Gunnar Naulaers; Petra Lemmers; Frank van Bel; Martin Wolf; Sabine Van Huffel
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Paper Abstract

Cerebral Autoregulation, in clinical practice, is assessed by means of correlation or coherence analysis between mean arterial blood pressure (MABP) and cerebral blood flow (CBF). However, even though there is evidence linking cerebral autoregulation assessment with clinical outcome in preterm infants, available methods lack precision for clinical use. Classical methods, used for cerebral autoregulation, are influenced by the choice of parameters such as the length of the epoch under analysis and the choice of suitable frequency bands. The influence of these parameters, in the derived measurements for cerebral autoregulation, has not yet been evaluated. In this study, cerebral autoregulation was assessed using correlation, coherence, a modified version of coherence and transfer function gain, and phase. The influence of the extra-parameters on the final scores was evaluated by means of sensitivity analysis. The methods were applied to a database of 18 neonates with measurements of MABP and tissue oxygenation index (TOI). TOI reflects changes in CBF and was measured by means of near-infrared spectroscopy.

Paper Details

Date Published: 1 November 2012
PDF: 9 pages
J. Biomed. Opt. 17(11) 117003 doi: 10.1117/1.JBO.17.11.117003
Published in: Journal of Biomedical Optics Volume 17, Issue 11
Show Author Affiliations
Alexander Caicedo, Katholieke Univ. Leuven (Belgium)
Gunnar Naulaers, Katholieke Univ. Leuven (Belgium)
Petra Lemmers, Univ. Medical Ctr. Utrecht (Netherlands)
Frank van Bel, Univ. Hospital Zürich (Switzerland)
Martin Wolf, Univ. Medical Ctr. Utrecht (Netherlands)
Sabine Van Huffel, Katholieke Univ. Leuven (Belgium)

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