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Journal of Biomedical Optics

Test-retest assessment of cortical activation induced by repetitive transcranial magnetic stimulation with brain atlas-guided optical topography
Author(s): Fenghua Tian; F. Andrew Kozel; Amarnath S. Yennu; Paul E. Croarkin; Shawn M. McClintock; Kimberly S. Mapes; Mustafa M. Husain; Hanli Liu
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Paper Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a technology that stimulates neurons with rapidly changing magnetic pulses with demonstrated therapeutic applications for various neuropsychiatric disorders. Functional near-infrared spectroscopy (fNIRS) is a suitable tool to assess rTMS-evoked brain responses without interference from the magnetic or electric fields generated by the TMS coil. We have previously reported a channel-wise study of combined rTMS/fNIRS on the motor and prefrontal cortices, showing a robust decrease of oxygenated hemoglobin concentration (Δ[HbO2]) at the sites of 1-Hz rTMS and the contralateral brain regions. However, the reliability of this putative clinical tool is unknown. In this study, we develop a rapid optical topography approach to spatially characterize the rTMS-evoked hemodynamic responses on a standard brain atlas. A hemispherical approximation of the brain is employed to convert the three-dimensional topography on the complex brain surface to a two-dimensional topography in the spherical coordinate system. The test-retest reliability of the combined rTMS/fNIRS is assessed using repeated measurements performed two to three days apart. The results demonstrate that the Δ[HbO2] amplitudes have moderate-to-high reliability at the group level; and the spatial patterns of the topographic images have high reproducibility in size and a moderate degree of overlap at the individual level.

Paper Details

Date Published: 7 November 2012
PDF: 10 pages
J. Biomed. Opt. 17(11) 116020 doi: 10.1117/1.JBO.17.11.116020
Published in: Journal of Biomedical Optics Volume 17, Issue 11
Show Author Affiliations
Fenghua Tian, The Univ. of Texas at Arlington (United States)
F. Andrew Kozel, Univ. of South Florida (United States)
Amarnath S. Yennu, The Univ. of Texas at Arlington (United States)
Paul E. Croarkin, The Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Shawn M. McClintock, The Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Kimberly S. Mapes, The Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Mustafa M. Husain, The Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Hanli Liu, The Univ. of Texas at Arlington (United States)


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