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Journal of Biomedical Optics • Open Access

Optical microangiography provides correlation between microstructure and microvasculature of optic nerve head in human subjects
Author(s): Lin An; Murray Johnstone; Ruikang K. Wang

Paper Abstract

It is demonstrated that optical microangiography (OMAG) is capable of imaging the detailed microstructure and microvasculature of the in vivo human optic nerve head (ONH), including the prelaminar tissue, the lamina cribrosa, the scleral rim and the vessels in the region of the circle of Zin-Haller. For demonstration, an ultrahigh sensitive OMAG system operating in the 850 nm wavelength region and a 500 kHz A-scan rate resulting in a spatial resolution of ∼6  μm were used. It was shown that OMAG provides superior results for three-dimensional imaging of the ONH compared to conventional optical coherence tomography by simultaneously recording both the microstructure and the functional microcirculation. The blood supply to the tissues of the ONH is an essential physiologic parameter needed for clinical assessment of the health of the nerve.

Paper Details

Date Published: 5 November 2012
PDF: 6 pages
J. Biomed. Opt. 17(11) 116018 doi: 10.1117/1.JBO.17.11.116018
Published in: Journal of Biomedical Optics Volume 17, Issue 11
Show Author Affiliations
Lin An, Univ. of Washington (United States)
Murray Johnstone, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)

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