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Journal of Biomedical Optics • Open Access

Collagen I fiber density increases in lymph node positive breast cancers: pilot study
Author(s): Samata M. Kakkad; Meiyappan Solaiyappan; Pedram Argani; Saraswati Sukumar; Lisa K. Jacobs; Dieter Leibfritz; Zaver Bhujwalla; Kristine Glunde

Paper Abstract

Collagen I (Col1) fibers are a major structural component in the extracellular matrix of human breast cancers. In a preliminary pilot study, we explored the link between Col1 fiber density in primary human breast cancers and the occurrence of lymph node metastasis. Col1 fibers were detected by second harmonic generation (SHG) microscopy in primary human breast cancers from patients presenting with lymph node metastasis (+-+ (fiber volume=29.22%±4.72%, inter-fiber distance=2.25±0.45 μm)- (fiber volume=20.33%±5.56%, inter-fiber distance=2.88±1.07 μm)+-

Paper Details

Date Published: 1 November 2012
PDF: 7 pages
J. Biomed. Opt. 17(11) 116017 doi: 10.1117/1.JBO.17.11.116017
Published in: Journal of Biomedical Optics Volume 17, Issue 11
Show Author Affiliations
Samata M. Kakkad, Johns Hopkins Univ. (United States)
Meiyappan Solaiyappan, Johns Hopkins Univ. (United States)
Pedram Argani, Johns Hopkins Univ. (United States)
Saraswati Sukumar, Johns Hopkins Univ. (United States)
Lisa K. Jacobs, Johns Hopkins Univ. (United States)
Dieter Leibfritz, Univ Bremen (Germany)
Zaver Bhujwalla, Johns Hopkins Univ. (United States)
Kristine Glunde, Johns Hopkins Univ. (United States)


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