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Journal of Biomedical Optics

Measurement of the nonlinear optical response of low-density lipoprotein solutions from patients with periodontitis before and after periodontal treatment: evaluation of cardiovascular risk markers
Author(s): Andrea M. Monteiro; Maria A. N. Jardini; Viviana Giampaoli; Sarah Alves; Antonio M. Figueiredo Neto; Magnus A. Gidlund
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Paper Abstract

The Z-Scan (ZS) technique in the thermal regime has been used to measure the nonlinear optical response of low-density lipoprotein (LDL). The ZS technique is carried out in LDL from 40 patients with chronic periodontitis before and after three, six, and 12 months of periodontal treatment. Clinical parameters such as probing depths, bleeding on probing, total and differential white blood cells counts, lipid profiles, cytokine levels, and antibodies against oxidized LDL are also determined and compared over time. Before the treatment, the ZS experimental results reveal that the LDL particles of these patients are heavily modified. Only after 12 months of the periodontal treatment, the ZS results obtained reveal behavioral characteristics of healthy particles. This conclusion is also supported by complementary laboratorial analysis showing that the periodontal treatment induces systemic changes in several inflammatory markers.

Paper Details

Date Published: 8 November 2012
PDF: 7 pages
J. Biomed. Opt. 17(11) 115004 doi: 10.1117/1.JBO.17.11.115004
Published in: Journal of Biomedical Optics Volume 17, Issue 11
Show Author Affiliations
Andrea M. Monteiro, Univ. de São Paulo (Brazil)
Maria A. N. Jardini, State Univ. of São Paulo (Brazil)
Viviana Giampaoli, Univ. de São Paulo (Brazil)
Sarah Alves, Univ. Federal de São Paulo (Brazil)
Antonio M. Figueiredo Neto, Univ. de São Paulo (Brazil)
Magnus A. Gidlund, Univ. de São Paulo (Brazil)

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