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Journal of Biomedical Optics

Study on application of optical clearing technique in skin diseases
Author(s): Hao Shan; Yanmei Liang; Jingyi Wang; Yan Li
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Paper Abstract

So far, the study of the optical clearing is almost always about healthy tissue. However, the ultimate goal is to detect diseases for clinical application. Optical clearing on diseased skins is explored. The effect is evaluated by applying a combined liquid paraffin and glycerol mixed solution on several kinds of diseased skins in vitro. Scanning experiments from optical coherence tomography show that it has different effects among fibroma, pigmented nevus, and seborrheic keratosis. Based on the results, we conclude that different skin diseases have different compositions and structures, and their optical parameters and biological characteristics should be different, which implies that the optical clearing technique may have selectivity and may not be suitable for all kinds of skin diseases.

Paper Details

Date Published: 8 November 2012
PDF: 5 pages
J. Biomed. Opt. 17(11) 115003 doi: 10.1117/1.JBO.17.11.115003
Published in: Journal of Biomedical Optics Volume 17, Issue 11
Show Author Affiliations
Hao Shan, Nankai Univ. (China)
Yanmei Liang, Nankai Univ. (China)
Jingyi Wang, Nankai Univ. (China)
Yan Li, Tianjin Univ. (China)


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