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Journal of Biomedical Optics • Open Access

Photoacoustic tomography through a whole adult human skull with a photon recycler

Paper Abstract

Photoacoustic tomography (PAT) of the human brain is challenging due to the fact that the skull strongly absorbs and scatters light, and attenuates and distorts ultrasound as well. For the first time, we demonstrated the feasibility of PAT through a whole adult human skull. A photon recycler (PR) was built to increase light transmittance through the skull. Both a graphite target and a canine brain were imaged through the skull. Use of the PR was found to improve the photoacoustic signal-to-noise ratio by a factor of 2.4. In addition, subtraction of photoacoustic signals that arise from light absorption within the skull significantly improved the contrast of the target. Our results indicate that PAT can potentially be applied to in vivo human brain imaging.

Paper Details

Date Published: 2 November 2012
PDF: 3 pages
J. Biomed. Opt. 17(11) 110506 doi: 10.1117/1.JBO.17.11.110506
Published in: Journal of Biomedical Optics Volume 17, Issue 11
Show Author Affiliations
Liming Nie, Washington Univ. in St. Louis (United States)
Xin Cai, Washington Univ. in St. Louis (United States)
Konstantin I. Maslov, Washington Univ. in St. Louis (United States)
Alejandro Garcia-Uribe, Washington Univ. in St. Louis (United States)
Mark A. Anastasio, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


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