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Journal of Biomedical Optics • Open Access

Phase-resolved acoustic radiation force optical coherence elastography

Paper Abstract

Many diseases involve changes in the biomechanical properties of tissue, and there is a close correlation between tissue elasticity and pathology. We report on the development of a phase-resolved acoustic radiation force optical coherence elastography method (ARF-OCE) to evaluate the elastic properties of tissue. This method utilizes chirped acoustic radiation force to produce excitation along the sample's axial direction, and it uses phase-resolved optical coherence tomography (OCT) to measure the vibration of the sample. Under 500-Hz square wave modulated ARF signal excitation, phase change maps of tissue mimicking phantoms are generated by the ARF-OCE method, and the resulting Young's modulus ratio is correlated with a standard compression test. The results verify that this technique could efficiently measure sample elastic properties accurately and quantitatively. Furthermore, a three-dimensional ARF-OCE image of the human atherosclerotic coronary artery is obtained. The result indicates that our dynamic phase-resolved ARF-OCE method can delineate tissues with different mechanical properties.

Paper Details

Date Published: 2 November 2012
PDF: 3 pages
J. Biomed. Opt. 17(11) 110505 doi: 10.1117/1.JBO.17.11.110505
Published in: Journal of Biomedical Optics Volume 17, Issue 11
Show Author Affiliations
Wenjuan Qi, Beckman Laser Institute and Medical Clinic (United States)
Ruimin Chen, The Univ. of Southern California (United States)
Lidek Chou, Beckman Laser Institute and Medical Clinic (United States)
Gangjun Liu, Beckman Laser Institute and Medical Clinic (United States)
Jun Zhang, Beckman Laser Institute and Medical Clinic (United States)
Qifa Zhou, The Univ. of Southern California (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)


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