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Journal of Biomedical Optics • Open Access

Photoacoustic detection of functional responses in the motor cortex of awake behaving monkey during forelimb movement
Author(s): Janggun Jo; Hongyu Zhang; Paul Cheney; Xinmai Yang

Paper Abstract

Photoacoustic (PA) imaging was applied to detect the neuronal activity in the motor cortex of an awake, behaving monkey during forelimb movement. An adult macaque monkey was trained to perform a reach-to-grasp task while PA images were acquired through a 30-mm diameter implanted cranial chamber. Increased PA signal amplitude results from an increase in regional blood volume and is interpreted as increased neuronal activity. Additionally, depth-resolved PA signals enabled the study of functional responses in deep cortical areas. The results demonstrate the feasibility of utilizing PA imaging for studies of functional activation of cerebral cortex in awake monkeys performing behavioral tasks.

Paper Details

Date Published: 22 October 2012
PDF: 3 pages
J. Biomed. Opt. 17(11) 110503 doi: 10.1117/1.JBO.17.11.110503
Published in: Journal of Biomedical Optics Volume 17, Issue 11
Show Author Affiliations
Janggun Jo, KU Bioengineering Research Ctr. (United States)
Hongyu Zhang, The Univ. of Kansas Medical Ctr. (United States)
Paul Cheney, The Univ. of Kansas Medical Ctr. (United States)
Xinmai Yang, KU Bioengineering Research Ctr. (United States)


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