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Journal of Biomedical Optics

Optical phantoms with variable properties and geometries for diffuse and fluorescence optical spectroscopy
Author(s): Barbara Leh; Rainer Siebert; Hussein Hamzeh; Laurent Ménard; Marie-Alix Duval; Yves Charon; Darine Abi-Haidar
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Paper Abstract

Growing interest in optical instruments for biomedical applications has increased the use of optically calibrated phantoms. Often associated with tissue modeling, phantoms allow the characterization of optical devices for clinical purposes. Fluorescent gel phantoms have been developed, mimicking optical properties of healthy and tumorous brain tissues. Specific geometries of dedicated molds offer multiple-layer phantoms with variable thicknesses and monolayer phantoms with cylindrical inclusions at various depths and diameters. Organic chromophores are added to allow fluorescence spectroscopy. These phantoms are designed to be used with 405 nm as the excitation wavelength. This wavelength is then adapted to excite large endogenous molecules. The benefits of these phantoms in understanding fluorescence tissue analysis are then demonstrated. In particular, detectability aspects as a function of geometrical and optical parameters are presented and discussed.

Paper Details

Date Published: 4 October 2012
PDF: 10 pages
J. Biomed. Opt. 17(10) 108001 doi: 10.1117/1.JBO.17.10.108001
Published in: Journal of Biomedical Optics Volume 17, Issue 10
Show Author Affiliations
Barbara Leh, Institut National de Physique Nucléaire et de Physique des Particules (France)
Rainer Siebert, Institut National de Physique Nucléaire et de Physique des Particules (France)
Hussein Hamzeh, Institut National de Physique Nucléaire et de Physique des Particules (France)
Laurent Ménard, Institut National de Physique Nucléaire et de Physique des Particules (France)
Marie-Alix Duval, Institut National de Physique Nucléaire et de Physique des Particules (France)
Yves Charon, Institut National de Physique Nucléaire et de Physique des Particules (France)
Darine Abi-Haidar, Institut National de Physique Nucléaire et de Physique des Particules (France)


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