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Journal of Biomedical Optics • Open Access

Simultaneous measurement of neuronal activity and cortical hemodynamics by unshielded magnetoencephalography and near-infrared spectroscopy
Author(s): Yusuke Seki; Tsuyoshi Miyashita; Akihiko Kandori; Atsushi Maki; Hideaki Koizumi

Paper Abstract

The correlation between neuronal activity and cortical hemodynamics, namely, neurovascular coupling (NVC), is important to shed light on the mechanism of a variety of brain functions or neuronal diseases. NVC can be studied by simultaneously measuring neuronal activity and cortical hemodynamics. Consequently, noninvasive measurements of the NVC have been widely studied using both electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). However, electromagnetic interference between EEG and fMRI is still a major problem. On the other hand, near-infrared spectroscopy (NIRS) is another promising tool for detecting cortical hemodynamics because it can be combined with EEG or magnetoencephalography (MEG) without any electromagnetic interference. Accordingly, in the present study, a simultaneous measurement system-combining an unshielded MEG using a two-dimensional gradiometer based on a low-<b<T</b< c superconducting quantum interference device (SQUID) and an NIRS using nonmagnetic thin probes-was developed. This combined system was used to simultaneously measure both an auditory-evoked magnetic field and blood flow change in the auditory cortex. It was experimentally demonstrated that the combined unshielded MEG/NIRS system can simultaneously measure neuronal activity and cortical hemodynamics.

Paper Details

Date Published: 1 October 2012
PDF: 6 pages
J. Biomed. Opt. 17(10) 107001 doi: 10.1117/1.JBO.17.10.107001
Published in: Journal of Biomedical Optics Volume 17, Issue 10
Show Author Affiliations
Yusuke Seki, Hitachi, Ltd. (Japan)
Tsuyoshi Miyashita, Hitachi, Ltd. (Japan)
Akihiko Kandori, Hitachi, Ltd. (Japan)
Atsushi Maki, Hitachi, Ltd. (Japan)
Hideaki Koizumi, Hitachi, Ltd. (Japan)


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