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Journal of Biomedical Optics • Open Access

Parapapillary atrophy and optic disc region assessment (PANDORA): retinal imaging tool for assessment of the optic disc and parapapillary atrophy
Author(s): Cheng-Kai Lu; Tong Boon Tang; Augustinus Laude; Baljean Dhillon; Alan F. Murray

Paper Abstract

We describe a computer-aided measuring tool, named parapapillary atrophy and optic disc region assessment (PANDORA), for automated detection and quantification of both the parapapillary atrophy (PPA) and the optic disc (OD) regions in two-dimensional color retinal fundus images. The OD region is segmented using a combination of edge detection and ellipse fitting methods. The PPA region is identified by the presence of bright pixels in the temporal zone of the OD, and it is segmented using a sequence of techniques, including a modified Chan-Vese approach, thresholding, scanning filter, and multiseed region growing. PANDORA has been tested with 133 color retinal images (82 with PPA; 51 without PPA) drawn randomly from the Lothian Birth Cohort (LBC) database, together with a "ground truth" estimate from an ophthalmologist. The PPA detection rate is 89.47% with a sensitivity of 0.83 and a specificity of 1. The mean accuracy in defining the OD region is 81.31% (

Paper Details

Date Published: 1 October 2012
PDF: 8 pages
J. Biomed. Opt. 17(10) 106010 doi: 10.1117/1.JBO.17.10.106010
Published in: Journal of Biomedical Optics Volume 17, Issue 10
Show Author Affiliations
Cheng-Kai Lu, The Univ. of Edinburgh (United Kingdom)
Tong Boon Tang, Univ. Teknologi Petronas (Malaysia)
Augustinus Laude, Tan Tock Seng Hospital (Singapore)
Baljean Dhillon, Princess Alexandra Eye Pavilion (United Kingdom)
Alan F. Murray, The Univ. of Edinburgh (United Kingdom)

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