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Journal of Biomedical Optics

Mesh-based Monte Carlo method in time-domain widefield fluorescence molecular tomography
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Paper Abstract

We evaluated the potential of mesh-based Monte Carlo (MC) method for widefield time-gated fluorescence molecular tomography, aiming to improve accuracy in both shape discretization and photon transport modeling in preclinical settings. An optimized software platform was developed utilizing multithreading and distributed parallel computing to achieve efficient calculation. We validated the proposed algorithm and software by both simulations and in vivo studies. The results establish that the optimized mesh-based Monte Carlo (mMC) method is a computationally efficient solution for optical tomography studies in terms of both calculation time and memory utilization. The open source code, as part of a new release of mMC, is publicly available at http://mcx.sourceforge.net/mmc/.

Paper Details

Date Published: 1 October 2012
PDF: 8 pages
J. Biomed. Opt. 17(10) 106009 doi: 10.1117/1.JBO.17.10.106009
Published in: Journal of Biomedical Optics Volume 17, Issue 10
Show Author Affiliations
Jin Chen, Rensselaer Polytechnic Institute (United States)
Qianqian Fang, Massachusetts General Hospital (United States)
Xavier Intes, Rensselaer Polytechnic Institute (United States)


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