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Journal of Biomedical Optics

Intravascular photoacoustic imaging at 35 and 80 MHz
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Paper Abstract

The catheter-based intravascular photoacoustic (IVPA) imaging for diagnosing atherosclerosis, which can provide optical absorption contrast of the arterial wall besides acoustic scattering contrast from the conventional intravascular ultrasound (IVUS) imaging, has been intensively researched recently. The resolution of IVPA is determined by the frequency bandwidth of an ultrasonic transducer. Higher resolution can be achieved by increasing the transducer's working frequency and bandwidth. We introduce IVPA imaging at 35 and 80 MHz by using newly designed integrated IVUS/IVPA probes. This is the first time IVPA has been achieved as high as 80 MHz. Six-micrometer tungsten wires were imaged to evaluate the probes' spatial resolutions and beam patterns. Healthy rabbit aorta was imaged in vitro. Imaging results show that IVPA has superior contrast over IVUS in identifying the arterial wall, and IVPA at 80 MHz demonstrates extraordinary resolution (35 μm) compared to 35 MHz.

Paper Details

Date Published: 1 October 2012
PDF: 6 pages
J. Biomed. Opt. 17(10) 106005 doi: 10.1117/1.JBO.17.10.106005
Published in: Journal of Biomedical Optics Volume 17, Issue 10
Show Author Affiliations
Xiang Li, The Univ. of Southern California (United States)
Wei Wei, Univ. of California, Irvine (United States)
Qifa Zhou, The Univ. of Southern California (United States)
K. Kirk Shung, The Univ. of Southern California (United States)
Zhongping Chen, Univ. of California, Irvine (United States)


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