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Journal of Biomedical Optics • Open Access

Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism
Author(s): Jae Gwan Kim; Jangwoen Lee; Sari Mahon; David Mukai; Steven E. Patterson; Gerry R. Ross; Bruce J. Tromberg; Matthew Brenner

Paper Abstract

Noninvasive near infrared spectroscopy measurements were performed to monitor cyanide (CN) poisoning and recovery in the brain region and in foreleg muscle simultaneously, and the effects of a novel CN antidote, sulfanegen sodium, on tissue hemoglobin oxygenation changes were compared using a sub-lethal rabbit model. The results demonstrated that the brain region is more susceptible to CN poisoning and slower in endogenous CN detoxification following exposure than peripheral muscles. However, sulfanegen sodium rapidly reversed CN toxicity, with brain region effects reversing more quickly than muscle. In vivo monitoring of multiple organs may provide important clinical information regarding the extent of CN toxicity and subsequent recovery, and facilitate antidote drug development.

Paper Details

Date Published: 1 October 2012
PDF: 6 pages
J. Biomed. Opt. 17(10) 105005 doi: 10.1117/1.JBO.17.10.105005
Published in: Journal of Biomedical Optics Volume 17, Issue 10
Show Author Affiliations
Jae Gwan Kim, Beckman Laser Institute and Medical Clinic (United States)
Jangwoen Lee, Beckman Laser Institute and Medical Clinic (United States)
Sari Mahon, Beckman Laser Institute and Medical Clinic (United States)
David Mukai, Beckman Laser Institute and Medical Clinic (United States)
Steven E. Patterson, Univ. of Minnesota, Twin Cities (United States)
Gerry R. Ross, Univ. of California, San Diego (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)
Matthew Brenner, Univ. of California, Irvine (United States)


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