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Journal of Biomedical Optics

Quantitative estimation of mechanical and optical properties from ultrasound assisted optical tomography data
Author(s): Mayanglambam S. Singh; Kanhirodan Rajan; Ram M. Vasu; Debasish Roy
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Paper Abstract

We demonstrate quantitative optical property and elastic property imaging from ultrasound assisted optical tomography data. The measurements, which are modulation depth M and phase ϕ of the speckle pattern, are shown to be sensitively dependent on these properties of the object in the insonified focal region of the ultrasound (US) transducer. We demonstrate that Young's modulus (E) can be recovered from the resonance observed in M versus ω (the US frequency) plots and optical absorption (μa) and scattering (μs) coefficients from the measured differential phase changes. All experimental observations are verified also using Monte Carlo simulations.

Paper Details

Date Published: 22 June 2012
PDF: 6 pages
J. Biomed. Opt. 17(10) 101507 doi: 10.1117/1.JBO.17.10.101507
Published in: Journal of Biomedical Optics Volume 17, Issue 10
Show Author Affiliations
Mayanglambam S. Singh, Indian Institute of Science (India)
Kanhirodan Rajan, Indian Institute of Science (India)
Ram M. Vasu, Indian Institute of Science (India)
Debasish Roy, Indian Institute of Science (India)


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