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Journal of Biomedical Optics • Open Access

In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography
Author(s): Ravi K. Manapuram; Salavat R. Aglyamov; Floredes M. Monediado; Maleeha Mashiatulla; Jiasong Li; Stanislav Y. Emelianov; Kirill V. Larin

Paper Abstract

We report a highly sensitive method based on phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to measure elastic wave propagation in soft tissues in vivo. The waves were introduced using a mechanical stimulus and were assessed using the phase response of the swept source optical coherence tomography signal. The technique was utilized to measure age-related changes in elastic flexural wave velocity and attenuation in mice cornea in vivo. Results demonstrate that the wave velocity increases with animal age, supporting previous observations that stiffness of mice cornea gradually increases with age. Our studies suggest that the PhS-SSOCE technique could potentially be used to obtain biomechanical properties of ocular tissues in vivo.

Paper Details

Date Published: 26 September 2012
PDF: 3 pages
J. Biomed. Opt. 17(10) 100501 doi: 10.1117/1.JBO.17.10.100501
Published in: Journal of Biomedical Optics Volume 17, Issue 10
Show Author Affiliations
Ravi K. Manapuram, Univ. of Houston (United States)
Salavat R. Aglyamov, The Univ. of Texas at Austin (United States)
Floredes M. Monediado, Univ. of Houston (United States)
Maleeha Mashiatulla, Univ. of Houston (United States)
Jiasong Li, Univ. of Houston (United States)
Stanislav Y. Emelianov, The Univ. of Texas at Austin (United States)
Kirill V. Larin, Univ. of Houston (United States)

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