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Journal of Biomedical Optics • Open Access

Preliminary evaluation of optical glucose sensing in red cell concentrations using near-infrared diffuse-reflectance spectroscopy
Author(s): Yusuke Suzuki; Katsuhiko Maruo; Alice Zhang; Kazushige Shimogaki; Hideto Ogawa; Fumiya Hirayama

Paper Abstract

Bacterial contamination of blood products is one of the most frequent infectious complications of transfusion. Since glucose levels in blood supplies decrease as bacteria proliferate, it should be possible to detect the presence of bacterial contamination by measuring the glucose concentrations in the blood components. Hence this study is aimed to serve as a preliminary study for the nondestructive measurement of glucose level in transfusion blood. The glucose concentrations in red blood cell (RBC) samples were predicted using near-infrared diffuse-reflectance spectroscopy in the 1350 to 1850 nm wavelength region. Furthermore, the effects of donor, hematocrit level, and temperature variations among the RBC samples were observed. Results showed that the prediction performance of a dataset which contained samples that differed in all three parameters had a standard error of 29.3  mg/dL. Multiplicative scatter correction (MSC) preprocessing method was also found to be effective in minimizing the variations in scattering patterns created by various sample properties. The results suggest that the diffuse-reflectance spectroscopy may provide another avenue for the detection of bacterial contamination in red cell concentrations (RCC) products.

Paper Details

Date Published: 7 February 2012
PDF: 8 pages
J. Biomed. Opt. 17(1) 017004 doi: 10.1117/1.JBO.17.1.017004
Published in: Journal of Biomedical Optics Volume 17, Issue 1
Show Author Affiliations
Yusuke Suzuki, Panasonic Electric Works Co., Ltd. (Japan)
Katsuhiko Maruo, Panasonic Electric Works Co., Ltd. (Japan)
Alice Zhang, The Univ. of British Columbia (Canada)
Kazushige Shimogaki, Osaka Red Cross Blood Ctr. (Japan)
Hideto Ogawa, Osaka Red Cross Blood Ctr. (Japan)
Fumiya Hirayama, Osaka Red Cross Blood Ctr. (Japan)

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