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Journal of Biomedical Optics

Exhaled nitric oxide monitoring by quantum cascade laser: comparison with chemiluminescent and electrochemical sensors
Author(s): Julien Mandon; Marieann Högman; Peter J. F. M. Merkus; Jan van Amsterdam; Frans J. M. Harren; Simona M. Cristescu
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Paper Abstract

Fractional exhaled nitric oxide (FENO) is considered an indicator in the diagnostics and management of asthma. In this study we present a laser-based sensor for measuring FENO. It consists of a quantum cascade laser (QCL) combined with a multi-pass cell and wavelength modulation spectroscopy for the detection of NO at the sub-part-per-billion by volume (ppbv, 1∶10−9) level. The characteristics and diagnostic performance of the sensor were assessed. A detection limit of 0.5 ppbv was demonstrated with a relatively simple design. The QCL-based sensor was compared with two market sensors, a chemiluminescent analyzer (NOA 280, Sievers) and a portable hand-held electrochemical analyzer (MINO®, Aerocrine AB, Sweden). FENO from 20 children diagnosed with asthma and treated with inhaled corticosteroids were measured. Data were found to be clinically acceptable within 1.1 ppbv between the QCL-based sensor and chemiluminescent sensor and within 1.7 ppbv when compared to the electrochemical sensor. The QCL-based sensor was tested on healthy subjects at various expiratory flow rates for both online and offline sampling procedures. The extended NO parameters, i.e. the alveolar region, airway wall, diffusing capacity, and flux were calculated and showed a good agreement with the previously reported values.

Paper Details

Date Published: 1 February 2012
PDF: 8 pages
J. Biomed. Opt. 17(1) 017003 doi: 10.1117/1.JBO.17.1.017003
Published in: Journal of Biomedical Optics Volume 17, Issue 1
Show Author Affiliations
Julien Mandon, Radboud Univ. Nijmegen (Netherlands)
Marieann Högman, Uppsala Univ. (Sweden)
Peter J. F. M. Merkus, Radboud Univ. Nijmegen Medical Ctr. (Netherlands)
Jan van Amsterdam, Rijksinstituut voor Volksgezondheid en Milieu (Netherlands)
Frans J. M. Harren, Radboud Univ. Nijmegen (Netherlands)
Simona M. Cristescu, Radboud Univ. Nijmegen (Netherlands)

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