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Journal of Biomedical Optics

Consistency and distribution of reflectance confocal microscopy features for diagnosis of cutaneous T cell lymphoma
Author(s): Susanne Lange-Asschenfeldt; Jasmin Babilli; Marc Beyer; Eggert Stockfleth; Martina Ulrich; Francisca Rius-Diaz; Salvador Gonzalez
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Paper Abstract

Reflectance confocal microscopy (RCM) represents a noninvasive imaging technique that has previously been used for characterization of mycosis fungoides (MF) in a pilot study. We aimed to test the applicability of RCM for diagnosis and differential diagnosis of MF in a clinical study. A total of 39 test sites of 15 patients with a biopsy-proven diagnosis of either MF, parapsoriasis, Sézary syndrome, or lymphomatoid papulosis were analyzed for presence and absence of RCM features of MF. Cochran and Chi2 analysis were applied to test the concordance between investigators and the distribution of RCM features, respectively. For selected parameters, the Cochran analysis showed good concordance between investigators. Inter-observer reproducibility was highest for junctional atypical lymphocytes, architectural disarray, and spongiosis. Similarly, Chi2 analysis demonstrated that selected features were present at particularly high frequency in individual skin diseases, with values ranging from 73% to 100% of all examined cases.

Paper Details

Date Published: 31 January 2012
PDF: 8 pages
J. Biomed. Opt. 17(1) 016001 doi: 10.1117/1.JBO.17.1.016001
Published in: Journal of Biomedical Optics Volume 17, Issue 1
Show Author Affiliations
Susanne Lange-Asschenfeldt, Charité Universitätsmedizin Berlin (Germany)
Jasmin Babilli, Charité Universitätsmedizin Berlin (Germany)
Marc Beyer, Charité Universitätsmedizin Berlin (Germany)
Eggert Stockfleth, Charité Universitätsmedizin Berlin (Germany)
Martina Ulrich, Charité Universitätsmedizin Berlin (Germany)
Francisca Rius-Diaz, Univ. de Málaga (Spain)
Salvador Gonzalez, Memorial Sloan-Kettering Cancer Ctr. (United States)

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