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Optical Engineering

Low-cost frequency-domain photon migration instrument for tissue spectroscopy, oximetry, and imaging
Author(s): Yunsong Yang; Hanli Liu; Xingde Li; Britton Chance
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Paper Abstract

We described a low-cost, frequency-domain photon migration spectroscopy instrument by using in-phase and quadrature demodulation technique in a 140-MHz homodyne system. A time constant of 1 ms was obtained. A frequency-division multiplexing technique was used for multiposition or multiwavelength applications, such as for tissue oximetry. By conducting several experiments on tissue/blood models, we show that the optical properties of tissue can be determined with this system by either using multiple source-detector separations at accuracy better than 8% or using single source-detector separation. The accuracy with the latter method can be improved to be 10% or better by choosing a proper calibration sample. A frequency-sweep system (30 to 700 MHz) was also implemented; the phase and amplitude measured on a tissuelike solution at 780 nm agreed to their theoretical values within 5% and 10% accuracy, respectively.

Paper Details

Date Published: 1 May 1997
PDF: 8 pages
Opt. Eng. 36(5) doi: 10.1117/1.601354
Published in: Optical Engineering Volume 36, Issue 5
Show Author Affiliations
Yunsong Yang, Univ. of Pennsylvania (United States)
Hanli Liu, Univ. of Texas at Arlington (United States)
Xingde Li, Univ. of Pennsylvania (United States)
Britton Chance, Univ. of Pennsylvania School of Medicine (United States)


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