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Journal of Biomedical Optics

Antibody-based biosensor for breast cancer with ultrasonic regeneration
Author(s): Maria C. Moreno-Bondi; Joel Mobley; Jean Pierre Alarie; Tuan Vo-Dinh
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Paper Abstract

We describe a novel method and instrumental setup for regenerating antibodies immobilized on a fiberoptic probe of an immunosensor using ultrasonic irradiation with broadband imaging transducers. The instrumental setup and irradiation conditions for antibody regeneration using ultrasound are described. The results of the measurements with antibody against breast cancer antigen illustrate the effectiveness and potential of the regenerable immunosensor. A 65% removal of the antigens bound to the Mab immobilized on the fiber surface is attained after ultrasound regeneration.

Paper Details

Date Published: 1 July 2000
PDF: 5 pages
J. Biomed. Opt. 5(3) doi: 10.1117/1.430006
Published in: Journal of Biomedical Optics Volume 5, Issue 3
Show Author Affiliations
Maria C. Moreno-Bondi, Univ. Complutense (Spain)
Joel Mobley, Oak Ridge National Lab. (United States)
Jean Pierre Alarie, Oak Ridge National Lab. (United States)
Tuan Vo-Dinh, Oak Ridge National Lab. (United States)

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