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Journal of Biomedical Optics

Three-dimensional diffuse optical mammography with ultrasound localization in a human subject
Author(s): Monica J. Holboke; Bruce J. Tromberg; Xing De Li; Natasha Shah; Joshua B. Fishkin; D. Kidney; John A. Butler; Britton Chance; Arjun G. Yodh
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Paper Abstract

We describe an approach that combines clinical ultrasound and photon migration techniques to enhance the sensitivity and information content of diffuse optical tomography. Measurements were performed on a postmenopausal woman with a single 1.8x0.9 cm malignant ductal carcinoma in situ approximately 7.4 mm beneath the skin surface (UCI IRB protocol 95-563). The ultrasound-derived information about tumor geometry enabled us to segment the breast tissue into tumor and background regions. Optical data was obtained with a multifrequency, multiwavelength hand-held frequency-domain photon migration backscattering probe. The optical properties of the tumor and background were then computed using the ultrasoundderived geometrical constraints. An iterative perturbative approach, using parallel processing, provided quantitative information about scattering and absorption simultaneously with the ability to incorporate and resolve complex boundary conditions and geometries. A three to four fold increase in the tumor absorption coefficient and nearly 50% reduction in scattering coefficient relative to background was observed (?=674, 782, 803, and 849 nm). Calculations of the mean physiological parameters reveal fourfold greater tumor total hemoglobin concentration [Hbtot] than normal breast (67 µM vs 16 µM) and tumor hemoglobin oxygen saturation (SOx) values of 63% (vs 73% and 68% in the region surrounding the tumor and the opposite normal tissue, respectively). Comparison of semi-infinite to heterogeneous models shows superior tumor/background contrast for the latter in both absorption and scattering. Sensitivity studies assessing the impact of tumor size and refractive index assumptions, as well as scan direction, demonstrate modest effects on recovered properties.

Paper Details

Date Published: 1 April 2000
PDF: 11 pages
J. Biomed. Opt. 5(2) doi: 10.1117/1.429992
Published in: Journal of Biomedical Optics Volume 5, Issue 2
Show Author Affiliations
Monica J. Holboke, Univ. of Pennsylvania (United States)
Bruce J. Tromberg, Univ. of California/Irvine (United States)
Xing De Li, Massachusetts Institute of Technology (United States)
Natasha Shah, Univ. of California/Irvine (United States)
Joshua B. Fishkin, Beckman Laser Institute and Medical Clinic (United States)
D. Kidney, Univ. of California Irvine Medical Center (United States)
John A. Butler, Univ. of California/Irvine (United States)
Britton Chance, Univ. of Pennsylvania (United States)
Arjun G. Yodh, Univ. of Pennsylvania (United States)

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