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Journal of Biomedical Optics

Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results
Author(s): Irving J. Bigio; Stephen G. Bown; Gavin M. Briggs; Christine Kelley; Sunil Lakhani; David Christopher O. Pickard; Paul M. Ripley; Ian Rose; Christobel Saunders
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Paper Abstract

We report on the first stages of a clinical study designed to test elastic-scattering spectroscopy, mediated by fiberoptic probes, for three specific clinical applications in breast-tissue diagnosis: (1) a transdermal-needle (interstitial) measurement for instant diagnosis with minimal invasiveness similar to fine-needle aspiration but with sensitivity to a larger tissue volume, (2) a hand-held diagnostic probe for use in assessing tumor/resection margins during open surgery, and (3) use of the same probe for real-time assessment of the ‘‘sentinel’’ node during surgery to determine the presence or absence of tumor (metastatic). Preliminary results from in vivo measurements on 31 women are encouraging. Optical spectra were measured on 72 histology sites in breast tissue, and 54 histology sites in sentinel nodes. Two different artificial intelligence methods of spectral classification were studied. Artificial neural networks yielded sensitivities of 69% and 58%, and specificities of 85% and 93%, for breast tissue and sentinel nodes, respectively. Hierarchical cluster analysis yielded sensitivities of 67% and 91%, and specificities of 79% and 77%, for breast tissue and sentinel nodes, respectively. These values are expected to improve as the data sets continue to grow and more sophisticated data preprocessing is employed. The study will enroll up to 400 patients over the next two years.

Paper Details

Date Published: 1 April 2000
PDF: 8 pages
J. Biomed. Opt. 5(2) doi: 10.1117/1.429990
Published in: Journal of Biomedical Optics Volume 5, Issue 2
Show Author Affiliations
Irving J. Bigio, Los Alamos National Lab. (United States)
Stephen G. Bown, Univ. College London National Medical Laser Ctr. (United Kingdom)
Gavin M. Briggs, National Laser Medical Ctr. (United Kingdom)
Christine Kelley, Los Alamos National Laboratory (United States)
Sunil Lakhani, Univ. College London (United Kingdom)
David Christopher O. Pickard, Royal Free and Univ. College London (United Kingdom)
Paul M. Ripley, Los Alamos National Lab. (United States)
Ian Rose, Los Alamos National Laboratory (United States)
Christobel Saunders, Univ. College London (United Kingdom)

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