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Journal of Biomedical Optics

Preliminary evaluation of dual wavelength phased array imaging on neonatal brain function
Author(s): Yu Chen; Shuoming Zhou; Chunhua Xie; Shoko Nioka; Maria Delivoria-Papadopoulos; Endla Anday; Britton Chance
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Paper Abstract

Imaging of human tissue using noninvasive techniques has been of great interest in biomedical fields. Optical imaging has attracted a lot of attention because of its portability and economy. The possibility that a highly portable, fast, safe, and affordable imaging system which could obtain interpretable images of brain function for pre- and full-term neonates in a few seconds, has been explored in this article. We have used a sensitive optical topography system, termed phased array, in which a pair of equal-amplitude and antiphase light sources are applied to generate a sharp amplitude null and phase transition plane. This two-wavelength (750 and 830 nm), frequency encoded (50 and 52 MHz) phased array imaging system can indicate the blood concentration and oxygenation changes in blood model studies and during parietal brain activation in neonates. Significant functional responses, particularly to parietal stimulation in normal and pathological states of neonatal brain, have been revealed in our study. The preliminary clinical results are presented in this article.

Paper Details

Date Published: 1 April 2000
PDF: 7 pages
J. Biomed. Opt. 5(2) doi: 10.1117/1.429986
Published in: Journal of Biomedical Optics Volume 5, Issue 2
Show Author Affiliations
Yu Chen, Univ. of Pennsylvania (United States)
Shuoming Zhou, Univ. of Pennsylvania (United States)
Chunhua Xie, Univ. of Pennsylvania (United States)
Shoko Nioka, Univ. of Pennsylvania School of Medicine (United States)
Maria Delivoria-Papadopoulos, Allegheny Univ. Hospital (United States)
Endla Anday, Allegheny Univ. Hospital (United States)
Britton Chance, Univ. of Pennsylvania (United States)


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