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Journal of Biomedical Optics

Activation of visual cortex imaged by 24 channel near-infrared spectroscopy
Author(s): Kazumi Takahashi; S. Ogata; R. Yamamoto; S. Shiotsuka; Atsushi Maki; Yuichi Yamashita; Tsuyoshi Yamamoto; Hideaki Koizumi; H. Hirasawa; M. Igawa; Y. Atsumi
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Paper Abstract

Near-infrared spectroscopy (NIRS) is a noninvasive technique for continuous monitoring of the amounts of total hemoglobin (total-Hb), oxygenated hemoglobin, (oxy-Hb) and deoxygenated hemoglobin (deoxy-Hb). The purpose of the present study was to demonstrate the utility of NIRS in functional imaging of the human visual cortex. A new NIRS imaging system enabled measurements from 24 scalp locations covering a 9 cm sq area. Topographic images were obtained from interpolations of the concentration changes between measurement points. Five healthy subjects between 25 and 49 years of age were investigated. After a resting baseline period of 50 s, the subjects were exposed to a visual stimulus for 20 s, followed by a 50 s resting period in a dimly lit, sound attenuating room. The visual stimulus was a circular, black and white, alternating checkerboard. In four of five subjects the visual cortex was the most activated area during visual stimulation. This is the first reported use of a NIRSimaging system for assessing hemodynamic changes in the human visual cortex. The typical hemodynamic changes expected were observed; the total-Hb and oxy-Hb increased just after the start of stimulation and plateaued after 10 s of the stimulation period.

Paper Details

Date Published: 1 January 2000
PDF: 4 pages
J. Biomed. Opt. 5(1) doi: 10.1117/1.429973
Published in: Journal of Biomedical Optics Volume 5, Issue 1
Show Author Affiliations
Kazumi Takahashi, Tokyo Metropolitan Matsuzawa Hospital (Japan)
S. Ogata, Tokyo Medical and Dental Univ. (Japan)
R. Yamamoto, Tokyo Medical and Dental University (Japan)
S. Shiotsuka, Tokyo Medical and Dental University (Japan)
Atsushi Maki, Hitachi, Ltd. (Japan)
Yuichi Yamashita, Hitachi, Ltd. (Japan)
Tsuyoshi Yamamoto, Hitachi, Ltd. (Japan)
Hideaki Koizumi, Hitachi, Ltd. (Japan)
H. Hirasawa, Tokyo Metropolitan Geriatric Hospital (Japan)
M. Igawa, Tokyo Metropolitan Geriatric Hosptial (Japan)
Y. Atsumi, The National Institute of Special Education (Japan)


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