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Journal of Biomedical Optics

Optical analysis of cirrhotic liver by near infrared time resolved spectroscopy
Author(s): Toshihiro Nishio; Toshiyuki Kitai; Mitsuharu Miwa; Rei Takahashi; Yoshio Yamaoka
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Paper Abstract

The severity of liver cirrhosis was related with the optical properties of liver tissue. Various grades of liver cirrhosis were produced in rats by intraperitoneal injection of thioacetamide (TAA) for different periods: 4 weeks, 8 weeks, 12 weeks, and 16 weeks. Optical properties of the liver, absorption coefficient (µa) and scattering coefficient (µs'), were measured by near-infrared time-resolved spectroscopy. Histological examination confirmed cirrhotic changes in the liver, which were more severe in rats with TAA administration for longer periods. The ma increased in 4- and 8-week rats, and then decreased in 12- and 16-week rats. The µa of blood-free liver decreased as liver cirrhosis progressed. The hemoglobin content in the liver calculated from the µa values increased in 4- and 8-week rats and decreased in 12- and 16-week rats. The µs' decreased in the cirrhotic liver, probably reflecting the decrease in the mitochondria content. It was shown that µa and µs' determination is useful to assess the severity of liver cirrhosis.

Paper Details

Date Published: 1 October 1999
PDF: 5 pages
J. Biomed. Opt. 4(4) doi: 10.1117/1.429941
Published in: Journal of Biomedical Optics Volume 4, Issue 4
Show Author Affiliations
Toshihiro Nishio, Kyoto Univ. (Japan)
Toshiyuki Kitai, Univ. of Pennsylvania (Japan)
Mitsuharu Miwa, Hamamatsu Photonics KK (Japan)
Rei Takahashi, Kyoto Univ. (Japan)
Yoshio Yamaoka, Kyoto Univ. (Japan)


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