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Journal of Biomedical Optics

Spectral analysis of the porphyrins incorporation into human blood
Author(s): Rodica-Mariana Ion
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Paper Abstract

The porphyrins seem to be the most effective photosensitizers in photodynamic therapy of cancer. Monomers and dimers of sulfonated and nonsulfonated porphyrins [5,10,15,20-tetra-phenyl-porphyrin, 5,10,15,20-tetranaphtyl- porphyrin (TNP), 5,10,15,20-tetra-p-sulfonato-phenyl-porphyrin (TS4PP) and 5,10,15,20-tetra-psulfonato- naphtyl-porphyrin], are studied in this paper by means of different spectral methods (UV-vis, fluorescence and polarization fluorescence). The porphyrins as TNP seem to be the most effective photosensitizer especially in a DMSO:water binary mixture of solvent. Monomer–dimer and J-aggregation equilibria and the temperature dependence of TS4PP spectra are also studied in this paper. The incorporation of the forms of these porphyrins into blood cells is studied by means of the cytofluorimetric method.

Paper Details

Date Published: 1 July 1999
PDF: 8 pages
J. Biomed. Opt. 4(3) doi: 10.1117/1.429933
Published in: Journal of Biomedical Optics Volume 4, Issue 3
Show Author Affiliations
Rodica-Mariana Ion, S.C. Zecasin S.A. (Romania)

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