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Journal of Biomedical Optics

Tetrapyrrolic glycosylated macrocycles for an application in PDT
Author(s): Michel Momenteau; Philiippe Maillard; Marie-Anne De Belinay; Daniele Carrez; Alain F. Croisy
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Paper Abstract

The synthesis and characterization of amphiphilic glycoconjugated porphyrins, benzochlorin, and azaporphyrins were reported. Among these molecules, several were found to be efficient photosensitizers in an in vitro assay using the human tumoral cell line HT29. Moreover, glycosylated benzochlorin and azaporphyrins, whose absorption bands in the red region of the visible spectrum are substantially increased as compared to porphyrins, display a good photocytotoxicity on tumor cells after irradiation with wavelength above 590 nm.

Paper Details

Date Published: 1 July 1999
PDF: 21 pages
J. Biomed. Opt. 4(3) doi: 10.1117/1.429932
Published in: Journal of Biomedical Optics Volume 4, Issue 3
Show Author Affiliations
Michel Momenteau, Institut Curie (France)
Philiippe Maillard, Institut Curie (France)
Marie-Anne De Belinay, Centre Univ (France)
Daniele Carrez, Centre Univ/Inst Curie Sec Recherche (France)
Alain F. Croisy, Institut Curie (France)


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