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Journal of Biomedical Optics

Aggregation and disaggregation of erythrocytes in whole blood: study by backscattering technique
Author(s): Alexander V. Priezzhev; Olga M. Ryaboshapka; Nikolai N. Firsov; Igor V. Sirko
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Paper Abstract

The aggregation phenomenon is of great importance for the evaluation of performance of the microcirculation system because of its influence on the blood viscosity at low shear stresses. Some important features and consequences of this phenomenon in vivo can be predicted in the in vitro experiments using optical methods. These methods are considered to be the most informative and applicable not only for the basic study of the aggregation phenomenon, but also for the diagnosis of a number of diseases and for the monitoring of therapeutic treatment in clinics. Results presented in this paper prove that the backscattering technique allows one to detect different changes of aggregational ability and deformability of erythrocytes and to get reliable and reproducible results distinguishing normal blood and blood with different pathologies.

Paper Details

Date Published: 1 January 1999
PDF: 9 pages
J. Biomed. Opt. 4(1) doi: 10.1117/1.429923
Published in: Journal of Biomedical Optics Volume 4, Issue 1
Show Author Affiliations
Alexander V. Priezzhev, M.V. Lomonosov Moscow State Univ. (Russia)
Olga M. Ryaboshapka, NICTL (Russia)
Nikolai N. Firsov, Russian State Medical Univ. (Russia)
Igor V. Sirko, Russian State Medical Univ. (Russia)


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