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Journal of Biomedical Optics

Custom designed acoustic pulses
Author(s): Don C. Lamb; Jerri A. Tribble; Apostolos George Doukas; Thomas J. Flotte; Robert H. Ossoff; Lou Reinisch
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Paper Abstract

We have used a tunable, infrared, free-electron laser with a Pockels cell controlled pulse duration to generate photoacoustic pulses with separate variable rise times (from 15 to 100 ns), durations (100–400 ns), and amplitudes (0.005–0.1 MPa). The tunability of the free-electron laser across water absorption bands allows the rise time of the thermal-elastically generated acoustical pulsed to be varied, while a Pockels cell controls the duration and cross polarizers control the pressure amplitude. The mechanical effects of pressure transients on biological tissue can have dramatic consequences. In addition to cell necrosis, carefully controlled pressure transients can also be used for therapeutic applications, such as drug delivery and gene therapy. This technique permits systemic probing of how biological tissue is affected by stress transients.

Paper Details

Date Published: 1 April 1999
PDF: 7 pages
J. Biomed. Opt. 4(2) doi: 10.1117/1.429912
Published in: Journal of Biomedical Optics Volume 4, Issue 2
Show Author Affiliations
Don C. Lamb, Vanderbilt Univ. Medical Ctr. and Wellman Labs. of Photomedicine, Massachusetts Gen. Hosp. (United States)
Jerri A. Tribble, Vanderbilt Univ. Medical Center (United States)
Apostolos George Doukas, Massachusetts General Hospital (United States)
Thomas J. Flotte, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Robert H. Ossoff, Vanderbilt Univ. Medical Ctr. (United States)
Lou Reinisch, Vanderbilt Univ. Medical Ctr. (New Zealand)

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